Dookudu is about an honest police officer (Mahesh Babu) fighting a mafia gang and how he travels to Turkey in search of mafia leader, Prakash Raj. However, he discovers that his senior officer, Najar is hand-in-glove with the mafia. Samantha plays Mahesh Babu`s love interest who is his senior officer`s daughter. What will Mahesh Babu choose? His country or his love interest?